118689-07-9

Basic information

• Product Name: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
• Synonyms: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol;2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propane-1,2-diol;Fluconazole Diol IMpurity;Fluconazole EP Impurity F;Fluconazole impurity F (EP)
• CAS NO: 118689-07-9
• Molecular Formula: C₁₁H₁₁F₂N₃O₂
• Molecular Weight: 255.223
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 118689-07-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 490.042 °C at 760 mmHg
• Flash Point: 250.168 °C
• Appearance: /
• Density: 1.42
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(118689-07-9)
• EPA Substance Registry System: 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol(118689-07-9)

Safety Data

• Hazardous Substances Data: 118689-07-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 118689-07-9 differently. You can refer to the following data:
1. 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol is a diol impurity of the antifungal agent Fluconazole (F421000).
2. 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol (Fluconazole EP Impurity F) is a diol impurity of the antifungal agent Fluconazole (F421000).

InChI:InChI=1/C11H11F2N3O2/c12-8-1-2-9(10(13)3-8)11(18,5-17)4-16-7-14-6-15-16/h1-3,6-7,17-18H,4-5H2

Upstream product

• 288-88-0 1,2,4-Triazole 
• 219923-95-2 3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol 
• 156570-15-9 1-(2-(2,4-difluorophenyl)allyl)-1H-1,2,4-triazole 
• 86386-77-8 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 584-08-7 potassium carbonate 
• 149882-16-6 (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 149809-36-9 Toluene-4-sulfonic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 847952-06-1 2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propionic acid 
• 159553-75-0 Acetic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 141113-42-0 (S)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 

Downstream Products

• 159553-75-0 Acetic acid (S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl ester 
• 219923-96-3 (2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole 
• 219923-97-4 (2S)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole 
• 137234-62-9 voriconazole 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 137234-63-0 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol 
• 219923-85-0 (2S-cis)-1-{4-[4-(4-{[4-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-2-yl]methoxy}phenyl)-piperazin-1-yl]phenyl}-3-(1-methylethyl)-2-imidazolidinone 
• 219923-85-0 1-[4-(4-{4-[(2R,4S)-4-(2,4-Difluoro-phenyl)-4-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-2-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-3-isopropyl-imidazolidin-2-one 
• 141113-41-9 (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol 

Relevant articles and documents

Triazole aromatic alcohol heterocyclic ether derivative and preparing method and application thereof

The invention relates to a triazole aromatic alcohol heterocyclic ether derivative and the preparing method and application thereof, and particularly provides the general structure, crystal form, pharmaceutically acceptable inorganic acid salt or organic acid salt, aquo-complex, and solvate or prodrug of the triazole aromatic alcohol heterocyclic ether derivative. In-vitro and in-vivo bacteriostasis experiments prove that the compound has remarkable activity in inhibiting human body pathomycete candida albicans, candida parapsilosis, cryptococcus neoformans, candida glabrata, aspergillus fumigates, gypseous microsporum and trichophyton rubrum, and the activity is higher than that of fluconazole. Furthermore, the compound has the advantages of being low in toxicity, wide in antifungal spectrum and the like, and therefore the compound can be used for preparing antifungal drugs.

Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology

In search for new compounds with potential for clinical use as antifungal agents in dermatology, a series of 12 azole compounds were synthesized stereospecifically and investigated specifically for their activity against dermatophyte fungal infections in

Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof

A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: STR1