Technology Process of 1,6-dibenzyl-2,3,5,6-tetrahydro-1H,4H-1,3a,6,8-tetraazaphenalene
There total 15 articles about 1,6-dibenzyl-2,3,5,6-tetrahydro-1H,4H-1,3a,6,8-tetraazaphenalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2,3,4,5-tetrahydro-1,3a,6,8-tetraazaphenalene-1,6-diyl)bis(phenylmethanone);
With
borane dimethyl sulphide complex;
In
tetrahydrofuran;
at 0 ℃;
for 17h;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol1029589
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen; potassium carbonate / ethanol / 48 h
3.1: pyridine / 6 h / 0 - 20 °C / Inert atmosphere
4.1: borane dimethyl sulphide complex / tetrahydrofuran / 17 h / 0 °C / Inert atmosphere; Reflux
4.2: 0 - 20 °C / Inert atmosphere
With
pyridine; borane dimethyl sulphide complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/ol1029589
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / 6 h / 0 - 20 °C / Inert atmosphere
2.1: borane dimethyl sulphide complex / tetrahydrofuran / 17 h / 0 °C / Inert atmosphere; Reflux
2.2: 0 - 20 °C / Inert atmosphere
With
pyridine; borane dimethyl sulphide complex;
In
tetrahydrofuran;
DOI:10.1021/ol1029589
