1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

Base Information

Chemical Name:1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one
CAS No.:1219624-75-5
Molecular Formula:C₃₁H₃₂F₃N₃O₂
Molecular Weight:535.609
Hs Code.:

Synonyms:1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

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Chemical Property of 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

Chemical Property:

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Technology Process of 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

There total 5 articles about 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60011-04-3
(2-oxo-3,3-diphenyl-piperidin-1-yl)-acetic acid

: 107890-32-4
1-(4-trifluoromethylbenzyl)piperazine

: 1219624-75-5
1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 3469-00-9
methyl 2,2-diphenylacetate

: 1219624-75-5
1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate

2: methanol; ammonia / Heating

3: potassium tert-butylate

4: water; lithium hydroxide / ethanol

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With methanol; dmap; potassium tert-butylate; ammonia; water; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100

Reference yield:

: 1219624-63-1
ethyl 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetate

: 1219624-75-5
1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / ethanol

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100