N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

Base Information

Chemical Name:N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide
CAS No.:1351091-68-3
Molecular Formula:C₁₈H₁₆N₆O₂S
Molecular Weight:380.43
Hs Code.:

Synonyms:N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

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Chemical Property of N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

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Technology Process of N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

There total 6 articles about N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1351091-33-2
3-[(6-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methylbenzenesulfonamide

: 1692-15-5
4-pyridylboronic acid

: 1351091-68-3
N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

Guidance literature:: With sodium carbonate; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 - 160 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 459434-40-3
3-amino-N-methylbenzenesulfonamide

: 1351091-68-3
N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: silver trifluoromethanesulfonate / isopropyl alcohol / 1.25 h / 120 °C / Microwave irradiation

2: sodium carbonate / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 - 160 °C / Microwave irradiation

With sodium carbonate; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; silver trifluoromethanesulfonate; In 1,4-dioxane; water; isopropyl alcohol;

Reference yield:

: 186519-89-1
7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1351091-68-3
N-methyl-3-{[6-(4-pyridinyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: silver trifluoromethanesulfonate / isopropyl alcohol / 1.25 h / 120 °C / Microwave irradiation

3.1: sodium carbonate / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 - 160 °C / Microwave irradiation

With sodium carbonate; lithium diisopropyl amide; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; silver trifluoromethanesulfonate; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol;