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186519-89-1

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186519-89-1 Usage

Description

4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic organic compound characterized by its molecular formula C15H9ClN4O2S. It features a pyrrolopyrimidine core structure and is recognized for its potential applications in pharmaceutical research and drug development. This chemical compound has garnered interest due to its possible biological activities and therapeutic uses, especially in addressing conditions such as cancer and inflammation. Its distinctive structural and chemical properties render it a promising candidate for further exploration and potential incorporation into the development of innovative medications.

Uses

Used in Pharmaceutical Research and Drug Development:
4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is utilized as a key intermediate in the synthesis of various pharmaceutical agents. Its unique structure and properties make it a valuable component in the creation of new drugs with potential applications in treating a range of diseases.
Used in Cancer Treatment:
In the field of oncology, 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is employed as a potential anticancer agent. Its biological activity is being studied for its capacity to target and inhibit the growth of cancer cells, offering a new avenue for therapeutic intervention in cancer treatment.
Used in Inflammation Management:
4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is also considered for use in managing inflammatory conditions. Its potential to modulate inflammatory responses is under investigation, with the aim of developing it into a treatment for various inflammatory diseases.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine serves as a structural template for the design and optimization of new pharmaceutical compounds. Its unique features facilitate the development of molecules with enhanced efficacy and selectivity for specific biological targets.
Used in Drug Discovery:
4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is utilized in high-throughput screening processes for drug discovery. Its presence in compound libraries allows researchers to identify potential lead candidates for further development into effective therapeutic agents.
Used in Chemical Synthesis:
In the chemical synthesis industry, 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is used as a building block for the creation of complex organic molecules. Its versatile chemical properties enable it to be a component in the synthesis of a variety of organic compounds with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 186519-89-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,5,1 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 186519-89:
(8*1)+(7*8)+(6*6)+(5*5)+(4*1)+(3*9)+(2*8)+(1*9)=181
181 % 10 = 1
So 186519-89-1 is a valid CAS Registry Number.

186519-89-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(benzenesulfonyl)-4-chloropyrrolo[2,3-d]pyrimidine

1.2 Other means of identification

Product number -
Other names AB3574

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:186519-89-1 SDS

186519-89-1Relevant articles and documents

Optochemical control of transcription by the use of 7-deaza-adenosine-based diarylethenes

Büllmann, Simon M.,Kolmar, Theresa,Slawetzky, Philip,Wald, Simon,J?schke, Andres

supporting information, p. 6596 - 6599 (2021/07/12)

Out of nine different 7-deaza-adenosine diarylethenes, we identified a high-performance photoswitch, suitable for the synthesis of photochromic DNA. By using solid phase synthesis, a photoresponsive T7 promotor was generated which allowed reversibly modulating the rate of enzymatic RNA synthesisin vitro.

IRREVERSIBLE INHIBITORS OF MENIN-MLL INTERACTION

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Paragraph 00522, (2020/07/21)

Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

3-HYDROXY-N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-1-CARBOXAMIDE DERIVATIVES

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Page/Page column 67-68, (2019/10/23)

The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions compris

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