1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone
CAS No.:1425732-48-4
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Suppliers and Price of 1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

There total 5 articles about 1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1425732-45-1
1-(4-(4-(2-nitrobenzyloxy)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

: 90-05-1
2-methoxy-phenol

: 1425732-48-4
1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 216h; Darkness;
DOI:10.1002/chem.201202498

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1425732-48-4
1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

1.2: 4 h / 0 - 20 °C / Inert atmosphere

1.3: 17 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 3 h / Inert atmosphere; Reflux

3.1: potassium carbonate / acetonitrile / 6.5 h / Inert atmosphere; Reflux

4.1: boron trifluoride diethyl etherate / dichloromethane / 216 h / 20 °C / Darkness

With boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; magnesium; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/chem.201202498

Reference yield:

: 203438-46-4
1-(4-(4-hydroxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

: 1425732-48-4
1-(4-(4-hydroxy-3-methoxyphenyl)-4-(4-(2-nitrobenzyloxy)phenyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 6.5 h / Inert atmosphere; Reflux

2: boron trifluoride diethyl etherate / dichloromethane / 216 h / 20 °C / Darkness

With boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1002/chem.201202498