methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

Base Information

Chemical Name:methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride
CAS No.:1428962-39-3
Molecular Formula:C₂₃H₂₆N₄O₆*ClH
Molecular Weight:490.944
Hs Code.:

Synonyms:methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

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Chemical Property of methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

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Technology Process of methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

There total 6 articles about methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428962-02-0
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate

: 1428962-39-3
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

Guidance literature:: With hydrogenchloride; In acetonitrile;
DOI:10.1016/j.bmc.2014.04.042

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1428962-39-3
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane / 1 h / 0 °C

2: potassium carbonate / acetonitrile / Reflux

3: hydrogenchloride / acetonitrile

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2014.04.042

Reference yield:

: 119-68-6
N-Methylanthranilic acid

: 1428962-39-3
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 5 h / 150 °C

2: sodium hydroxide; sodium sulfate / N,N-dimethyl-formamide / 5 h / 20 - 60 °C

3: methanol / 8 h / 20 °C

4: potassium carbonate / acetonitrile / Reflux

5: hydrogenchloride / acetonitrile

With hydrogenchloride; potassium carbonate; sodium sulfate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.042