(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

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Chemical Name:(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid
CAS No.:1430218-60-2
Molecular Formula:C₂₆H₂₃ClN₈O₄
Molecular Weight:546.973
Hs Code.:

Synonyms:(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

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Chemical Property of (E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

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Technology Process of (E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

There total 13 articles about (E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942316-73-6
(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid

: 1224444-35-2
tert-butyl 4-isocyanobenzoate

: 1430218-03-3
2,3-dimethyl-4,5-dihydro-2H-pyrazolo[3,4-c]pyridine

: 1430218-60-2
(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

Guidance literature:: (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid; tert-butyl 4-isocyanobenzoate; 2,3-dimethyl-4,5-dihydro-2H-pyrazolo[3,4-c]pyridine; With water; lithium hydroxide; In tetrahydrofuran; for 2h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 477721-50-9
tert-butyl 4-formamidobenzoate

: 1430218-60-2
(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; triethylamine / tetrahydrofuran / 2 h / 0 °C

2: methanol / 72 h / 55 °C / Sealed tube

3: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 2: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1430218-60-2
(E)-4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,3-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: neat (no solvent) / 24 h / Reflux

2: trichlorophosphate; triethylamine / tetrahydrofuran / 2 h / 0 °C

3: methanol / 72 h / 55 °C / Sealed tube

4: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 3: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171