(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

Base Information

Chemical Name:(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide
CAS No.:954426-15-4
Molecular Formula:C₂₅H₃₁N₃O₃Si
Molecular Weight:449.625
Hs Code.:

Synonyms:(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

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Chemical Property of (E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

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Technology Process of (E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

There total 4 articles about (E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₉ClN₂O₂Si

: 1485-71-8
benzophenone oxime

: 954426-15-4
(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

Guidance literature:: With sodium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol0711568

Reference yield:

: 954426-13-2
(2E)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)propenoic acid

: 954426-15-4
(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 4 h / 20 °C

2: 6.81 g / Na₂SO₄; Et₃N / CH₂Cl₂ / 3 h / 20 °C

With oxalyl dichloride; sodium sulfate; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/ol0711568

Reference yield:

: 574-66-3
Benzophenone oxime

: 954426-15-4
(E)-N-benzhydryl-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq. HCl; NaBH₃CN / methanol / 4 h / 20 °C / pH 3

2: 6.81 g / Na₂SO₄; Et₃N / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; sodium sulfate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/ol0711568