1485-71-8Relevant articles and documents
Synthesis and fungicidal activity of 2-(diphenylmethyl)-3-arylisoxazolidine-5-carboxamides
Zelechowski, Krzysztof,Golbiewski, W. Marek,Krawczyk, Maria
, p. 1895 - 1905 (2015)
A series of new 2-(diphenylmethyl)-3-arylisoxazolidine-5-carboxamides have been prepared from aldehydes. A key step was an uncatalyzed stereoselective and regioselective 1,3-dipolar cycloaddition reaction of N-benzylidene-N-diphenylmethyl nitrones with et
Phyllosilicate-derived Nickel-cobalt Bimetallic Nanoparticles for the Catalytic Hydrogenation of Imines, Oximes and N-heteroarenes
Ciotonea, Carmen,Hammi, Nisrine,Dhainaut, Jérémy,Marinova, Maya,Ungureanu, Adrian,El Kadib, Abdelkrim,Michon, Christophe,Royer, Sébastien
, p. 4652 - 4663 (2020/08/19)
The development of cost-effective, noble metal-free catalytic systems for the hydrogenation of unsaturated aliphatic, aromatic, and heterocyclic compounds is fundamental for future valorization of general feedstock. With this aim, we report here the preparation of highly dispersed bimetallic Ni/Co nanoparticles (NPs), by a one-pot deposition-precipitation of Ni and Co phases onto mesoporous SBA-15 silica. By adjusting the chemical composition in the starting mixture, three supported catalysts with different Ni to Co weight ratios were obtained, which were further subjected to treatments under reducing conditions at high temperatures. Characterization of the resulting solids evidenced a homogenous distribution of Ni and Co elements forming the NPs, the best results being obtained for Ni/Co-2 : 2 samples, for which 50 wt.percent Ni–50 wt.percent Co NPs are found located on the surface of the residual phyllosilicate. Ni/Co-2 : 2, presenting the best performances for the hydrogenation of 2-methyl-quinoline, was further evaluated in the catalytic hydrogenation of selected imines, oximes and N-heteroarenes. Due to the high dispersion of bimetallic Ni?Co NPs, excellent properties (activity and selectivity) in the conversion of the selected substrates are reported.
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 55-56, (2008/12/04)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
Studies toward the total synthesis of axinellamine and massadine
Sivappa, Rasapalli,Hernandez, Nora M.,He, Yong,Lovely, Carl J.
, p. 3861 - 3864 (2008/02/11)
Intramolecular Diels-Alder reactions of several N-O linked 4-vinylimidazole dimers provide the expected adduct in moderate to good yield as a single, all trans stereoisomer, along with smaller amounts of the inverse electron demand adduct. Oxidative rearr
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors
Gopalsamy, Ariamala,Yang, Hui,Ellingboe, John W.,McKew, John C.,Tam, Steve,Joseph-McCarthy, Diane,Zhang, Wen,Shen, Marina,Clark, James D.
, p. 2978 - 2981 (2008/09/21)
1,2,4-Oxadiazolidin-3,5-dione and 1,3,5-triazin-2,4,6-trione scaffolds were employed as templates to incorporate the pharmacophore requirements of cytosolic phospholipase A2α substrate mimetics. Inhibitors that are active in both enzyme, and ce
Amino acid-derived hydroxamic acids as chiral ligands in the vanadium catalysed epoxidation
Malkov, Andrei V.,Bourhani, Zainaba,Kocovsky, Pavel
, p. 3194 - 3200 (2007/10/03)
New sulfonamide-derived hydroxamic acids 7-11 have been developed as chiral ligands for the V-catalysed asymmetric epoxidation, showing high reactivity at subzero temperatures and moderate to good enantioselectivity. The strong accelerating effect exhibited by the ligands of this type can be attributed to the sulfonamide functionality. A range of cinnamyl type allylic alcohols were epoxidised with up to 74% ee. The Royal Society of Chemistry 2005.
Control of enantioselectivity through a hydrogen-bonded template in the vanadium(V)-catalyzed epoxidation of allylic alcohols by optically active hydroperoxides
Adam, Waldemar,Beck, Albert K.,Pichota, Arkadius,Saha-Moeller, Chantu R.,Seebach, Dieter,Vogl, Nadine,Zhang, Rui
, p. 1355 - 1361 (2007/10/03)
The vanadium(V)-catalyzed asymmetric epoxidation of primary allylic alcohols by the optically active TADDOL-derived hydroperoxide as the asymmetric controller provides the corresponding (R)-epoxides in up to 72% ee. From this mechanistic study we conclude
Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase
Shiino, Mitsuhiro,Watanabe, Yumi,Umezawa, Kazuo
, p. 1233 - 1240 (2007/10/03)
A series of N-substituted N-nitrosohydroxylamines including six new compounds were synthesized and examined for inhibition of mushroom tyrosinase. Corresponding hydroxylamines were reacted with n-butyl nitrite to give substituted nitrosohydroxylamines as their ammonium salt. The N-substituted hydroxylamines were prepared from the primary amines via the oxaziridine, or from the carbonyl compounds via the oxime. Most of the nitrosohydroxylamines tested inhibited mushroom tyrosinase. Among them, N-cyclopentyl-N-nitrosohydroxylamine exhibited the most potent activity (IC50=0.6 μM), as powerful as that of tropolone, one of the most powerful inhibitors. As removal of nitroso or hydroxyl moiety, the enzyme inhibitory activity was completely diminished. Both N-nitroso group and N-hydroxy group were suggested to be essential for the activity, probably by interacting with the copper ion at the active site of the enzyme. Lineweaver-Burk plotting showed that cupferron was a competitive inhibitor but that N-cyclopentyl-N-nitrosohydroxylamine was not.
A novel transformation of primary amines to N-monoalkylhydroxylamines
Tokuyama,Kuboyama,Amano,Yamashita,Fukuyama
, p. 1299 - 1304 (2007/10/03)
A novel transformation of primary amines to the corresponding N-monoalkylhydroxylamines is described. The three-step protocol involves selective mono-cyanomethylation of primary amines, regioselective formation of nitrones by m-CPBA oxidation, and hydroxylaminolysis of the nitrones with hydroxylamine hydrochloride. The method is applicable for a wide range of primary amines, including alkyl, benzyl, and chiral.
