1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

Base Information

Chemical Name:1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide
CAS No.:1221446-18-9
Molecular Formula:C₂₅H₃₇ClN₄O₂
Molecular Weight:461.047
Hs Code.:

Synonyms:1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

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Chemical Property of 1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

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Technology Process of 1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

There total 10 articles about 1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1221446-17-8
tert-butyl 8-(3-(1-acetyl-N-(3-chloro-4-methylphenyl)-4-piperidineformamide)propyl)-3-exo-8-azabicyclo[3.2.1]octan-3-carbamate

: 1221446-18-9
1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

Guidance literature:: tert-butyl 8-(3-(1-acetyl-N-(3-chloro-4-methylphenyl)-4-piperidineformamide)propyl)-3-exo-8-azabicyclo[3.2.1]octan-3-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;

With sodium hydroxide; In dichloromethane; water; pH=12;

Reference yield:

: 132259-54-2,287114-24-3
exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

: 1221446-18-9
1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

2.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

3.2: pH 12

With ammonium formate; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; potassium iodide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 132234-68-5
exo-3-<<(1,1-dimethylethoxy)carbonyl>amino>-8-azabicyclo<3.2.1>octane

: 1221446-18-9
1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

2.2: pH 12

With potassium carbonate; trifluoroacetic acid; potassium iodide; In dichloromethane; acetonitrile;