1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Base Information

Chemical Name:1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide
CAS No.:1221446-07-6
Molecular Formula:C₃₃H₄₄ClN₅O₄
Molecular Weight:610.196
Hs Code.:

Synonyms:1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

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Chemical Property of 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

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Technology Process of 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

There total 11 articles about 1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1221446-18-9
1-acetyl-N-(3-(3-exo-amino-8-azabicyclo[3.2.1]oct-8-yl)propyl)-N-(3-chloro-4-methylphenyl)-4-piperidinylcarboxamide

: 5416-93-3
4-Methoxyphenyl isocyanate

: 1221446-07-6
1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Guidance literature:: In dichloromethane; for 4h;

Reference yield:

: 76272-34-9
8-benzyl-8-azabicyclo[3.2.1] octan-3-one oxime

: 1221446-07-6
1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium; pentan-1-ol / 2 h / Reflux

2.1: triethylamine / dichloromethane / 12 h / Reflux

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

4.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

5.2: pH 12

6.1: dichloromethane / 4 h

With pentan-1-ol; ammonium formate; sodium; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; potassium iodide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 1221446-07-6
1-acetyl-N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(3-(4-methoxylphenyl)ureylene)-8-azabicyclo[3.2.1]oct-8-yl)propyl)-4-piperidinylcarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; water / 1 h / Reflux

1.2: 6 h / 0 - 50 °C

1.3: pH 12

2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux

3.1: sodium; pentan-1-ol / 2 h / Reflux

4.1: triethylamine / dichloromethane / 12 h / Reflux

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

6.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

7.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

7.2: pH 12

8.1: dichloromethane / 4 h

With pyridine; hydrogenchloride; pentan-1-ol; hydroxylamine hydrochloride; water; ammonium formate; sodium; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; potassium iodide; In methanol; ethanol; dichloromethane; acetonitrile;