(2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester

Base Information

• Chemical Name: (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester
• CAS No.: 944249-84-7
• Molecular Formula: C₁₈H₁₈O₅S
• Molecular Weight: 346.404
• Mol file: 944249-84-7.mol

Synonyms:(2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester

Chemical Property of (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester

There total 6 articles about (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-tosyloxybenzaldehyde (80459-48-9) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester (944249-84-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jacs.7b05619

Reference yield: 81.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 4-tosyloxybenzaldehyde (80459-48-9) → (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester (944249-84-7)

Guidance literature:

With triethylamine; lithium bromide; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1039/b704211f

Reference yield: 74.0%

4-vinylphenyl 4-methylbenzenesulfonate (80122-73-2) + ethylhydrazine carboxylate (4114-31-2) → (2E)-3-[4-(toluene-4-sulfonyloxy)phenyl]-2-propenoic acid ethyl ester (944249-84-7)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); oxygen; copper(l) chloride; In acetonitrile; at 70 ℃; for 5h; under 760.051 Torr; regioselective reaction; Schlenk technique; Molecular sieve;

DOI:10.1039/c3cc42994f

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

4-tosyloxybenzaldehyde

4-vinylphenyl 4-methylbenzenesulfonate

ethylhydrazine carboxylate

Downstream raw materials:

toluene-4-sulfonic acid 4-[(1E)-3-hydroxy-1-propenyl]phenyl ester

toluene-4-sulfonic acid 4-[(R)-1-(4-formyl-2-iodophenoxy)allyl]phenyl ester

toluene-4-sulfonic acid 4-[(2S,3R)-2,3-dihydro-5-formyl-3-methylbenzofuran-2-yl]phenyl ester

toluene-4-sulfonic acid 4-[(2R,3S)-2,3-dihydro-(3-methyl-5-(1E)-1-propenylbenzofuran-2-yl)]phenyl ester