1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

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Chemical Name:1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine
CAS No.:1349198-23-7
Molecular Formula:C₂₄H₂₄N₄O₃S
Molecular Weight:448.546
Hs Code.:

Synonyms:1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

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Chemical Property of 1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

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Technology Process of 1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

There total 4 articles about 1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1349198-29-3
tert-butyl 4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)benzyl(methyl)carbamate

: 1349198-23-7
1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

Guidance literature:: tert-butyl 4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)benzyl(methyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1349198-23-7
1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 72 h / Reflux

2.1: triethylamine; copper(l) iodide / toluene / 16 h / 20 °C / Inert atmosphere

3.1: sodium carbonate; methanol / 0.75 h / 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 65 °C

4.2: 1.75 h / 20 - 65 °C

5.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With methanol; N-chloro-succinimide; copper(l) iodide; sodium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1349198-26-0
2-chloro-6-(4-(isopropylsulfonyl)phenyl)pyrazine

: 1349198-23-7
1-(4-(5-(6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)isoxazol-3-yl)phenyl)-N-methylmethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; copper(l) iodide / toluene / 16 h / 20 °C / Inert atmosphere

2.1: sodium carbonate; methanol / 0.75 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 65 °C

3.2: 1.75 h / 20 - 65 °C

4.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With methanol; N-chloro-succinimide; copper(l) iodide; sodium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;