2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1201646-73-2
Molecular Formula:C₂₁H₁₅BrN₄
Molecular Weight:403.281
Hs Code.:

Synonyms:2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 15 articles about 2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1201646-70-9
2-(4-(3-amino-6-bromoquinolin-4-carbonyl)phenyl)-2-methylpropanenitrile

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 1201646-73-2
2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With formic acid; at 170 ℃; for 0.5h;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1201646-73-2
2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: chromium(VI) oxide; periodic acid / acetonitrile / 18 h / 20 °C

10.1: iron; acetic acid / 0.5 h / 20 °C

11.1: formic acid / 0.5 h / 170 °C

With chromium(VI) oxide; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; formic acid; potassium acetate; iron; sodium hydride; caesium carbonate; ozone; acetic acid; periodic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201646-73-2
2-(4-(9-bromopyrimido[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: chromium(VI) oxide; periodic acid / acetonitrile / 18 h / 20 °C

9.1: iron; acetic acid / 0.5 h / 20 °C

10.1: formic acid / 0.5 h / 170 °C

With chromium(VI) oxide; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; formic acid; potassium acetate; iron; caesium carbonate; ozone; acetic acid; periodic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;