Technology Process of 2-(4-(3-amino-6-bromoquinolin-4-carbonyl)phenyl)-2-methylpropanenitrile
There total 14 articles about 2-(4-(3-amino-6-bromoquinolin-4-carbonyl)phenyl)-2-methylpropanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron; acetic acid;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C
2.2: 25 °C
3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C
5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C
6.1: hydrogenchloride / acetone / 24 h
7.1: hydrogenchloride / water / 24 h
8.1: potassium acetate / ethanol / 5 h / Reflux
9.1: chromium(VI) oxide; periodic acid / acetonitrile / 18 h / 20 °C
10.1: iron; acetic acid / 0.5 h / 20 °C
With
chromium(VI) oxide; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; iron; sodium hydride; caesium carbonate; ozone; acetic acid; periodic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C
1.2: 25 °C
2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C
3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C
5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C
6.1: hydrogenchloride / acetone / 24 h
7.1: hydrogenchloride / water / 24 h
8.1: potassium acetate / ethanol / 5 h / Reflux
9.1: chromium(VI) oxide; periodic acid / acetonitrile / 18 h / 20 °C
10.1: iron; acetic acid / 0.5 h / 20 °C
With
chromium(VI) oxide; hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; iron; caesium carbonate; ozone; acetic acid; periodic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
