methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Base Information

Chemical Name:methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate
CAS No.:1280667-11-9
Molecular Formula:C₁₈H₁₇NO₈S
Molecular Weight:407.401
Hs Code.:

Synonyms:methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Chemical Property of methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Technology Process of methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

There total 5 articles about methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1280667-09-5
methyl 2-(hydroxymethyl)-7-nitro-2,3-dihydrobenzofuran-4-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1280667-11-9
methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 - 30 ℃; for 12h; Inert atmosphere;

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1280667-11-9
methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

2: 3 h / 190 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 - 30 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 12 h / 20 - 30 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dmap; In dichloromethane; acetonitrile;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1280667-11-9
methyl 7-nitro-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 2 h / 0 °C / Reflux; Inert atmosphere

2: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3: 3 h / 190 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 - 30 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 12 h / 20 - 30 °C / Inert atmosphere

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dmap; In dichloromethane; acetonitrile;