(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Base Information

Chemical Name:(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate
CAS No.:163457-37-2
Molecular Formula:C₂₁H₃₁FO₅Si
Molecular Weight:410.558
Hs Code.:

Synonyms:(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Suppliers and Price of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

There total 7 articles about (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 163457-33-8
(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-butyric acid

: 163457-40-7
p-fluorophenyl (2E)-4-hydroxy-2-butenoate

: 163457-37-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; for 12h; Ambient temperature;
DOI:10.1021/jo951653e

Reference yield:

: 163457-34-9
(+)-(4S)-3-<(2'R)-2'-((benzyloxy)methyl)butanoyl>-4-benzyl-2-oxazolidinone

: 163457-37-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd on carbon / ethanol / 72 h / Ambient temperature

2: 100 percent / 4-(N,N-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: aq. H₂O₂, LiOH*H₂O / tetrahydrofuran / 2 h / Ambient temperature

4: 100 percent / 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 12 h / Ambient temperature

With dmap; lithium hydroxide; hydrogen; dihydrogen peroxide; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e

Reference yield:

: 371-41-5
4-Fluorophenol

: 163457-37-2
(-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 14 h / Ambient temperature

2: 90 percent / aq. AcOH / tetrahydrofuran / 10 h / Ambient temperature

3: 100 percent / 4-(N,N-dimethylamino)pyridine, DCC / 1,2-dichloro-ethane / 12 h / Ambient temperature

With dmap; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/jo951653e