4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester

Base Information

• Chemical Name: 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester
• CAS No.: 521272-70-8
• Molecular Formula: C₂₃H₂₈N₂O₄
• Molecular Weight: 396.486

Synonyms:4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester

Chemical Property of 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester

Chemical Property:

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Technology Process of 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester

There total 3 articles about 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(-)-(R)-[(1'R,2'S,5'R)-2'-isopropyl-5'-methylcyclohexyl](2''-pyridyl)methanol (521272-67-3) + 4-nitro-benzoic acid (62-23-7) → 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester (521272-70-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 - 40 ℃; for 15h;

DOI:10.1039/b205872n

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester (521272-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg; 1,2-dibromoethane; I₂ / tetrahydrofuran / Heating

1.2: tetrahydrofuran / 12 h / Heating

2.1: 75 percent / PPh₃; diethyl azidodicarboxylate / tetrahydrofuran / 15 h / 20 - 40 °C

With iodine; magnesium; ethylene dibromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1039/b205872n

Reference yield:

(-)-menthyl chloride → 4-Nitro-benzoic acid (R)-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-pyridin-2-yl-methyl ester (521272-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg; 1,2-dibromoethane; I₂ / tetrahydrofuran / Heating

1.2: tetrahydrofuran / 12 h / Heating

2.1: 75 percent / PPh₃; diethyl azidodicarboxylate / tetrahydrofuran / 15 h / 20 - 40 °C

With iodine; magnesium; ethylene dibromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1039/b205872n

upstream raw materials:

(-)-(R)-[(1'R,2'S,5'R)-2'-isopropyl-5'-methylcyclohexyl](2''-pyridyl)methanol

4-nitro-benzoic acid

pyridine-2-carbaldehyde

Downstream raw materials:

(-)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl](2'-pyridyl)ketone

(-)-(S)-[(1'R,2'S,5'R)-2'-isopropyl-5'-methylcyclohexyl](2''-pyridyl)methanol

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