2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Name:2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283145-84-5
Molecular Formula:C₂₇H₂₈N₂O
Molecular Weight:396.532
Hs Code.:

Synonyms:2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

There total 6 articles about 2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 312693-19-9
(2-methylbenzyl)zinc(II)chloride

: 1283145-82-3
2-((2R,4R)-4-(benzyloxy)-1-(4-bromophenyl)pyrrolidin-2-yl)acetonitrile

: 1283145-84-5
2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; at 100 ℃; for 1h; Ineryt atmosphere;

Reference yield:

: 109953-95-9
tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1283145-84-5
2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

2: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 12 h / 90 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 0 °C

4: dimethyl sulfoxide / 4 h / 50 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 100 °C / Ineryt atmosphere

With hydrogenchloride; triethylamine; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 40350-83-2,54631-82-2,54631-81-1
(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

: 1283145-84-5
2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -10 °C

1.2: 0.5 h / 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

3.1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 12 h / 90 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C

5.1: dimethyl sulfoxide / 4 h / 50 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 100 °C / Ineryt atmosphere

With 4-methyl-morpholine; hydrogenchloride; triethylamine; sodium hydroxide; isobutyl chloroformate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;