(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Base Information

Chemical Name:(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester
CAS No.:691406-81-2
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Suppliers and Price of (S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

There total 8 articles about (S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691406-73-2
(S)-5-(2-phenyl-ethyl)-4-(N-[allyl]-2-amino-2-methoxycarbonyl-ethyl)-3-izoxazolecarboxylic acid ethyl ester

: 691406-81-2
(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Guidance literature:: With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 35 ℃; for 3h;
DOI:10.1021/ol049619m

Reference yield:

: 216962-12-8
3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester

: 691406-81-2
(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.17 h / cooling

1.2: tetrahydrofuran; hexane / 6 h

2.1: 92 percent / p-toluenesulfonic acid monohydrate / acetone

3.1: BF₃*OEt₂ / 0.17 h / cooling

3.2: 68 percent / lead(IV) acetate / benzene

4.1: 54 percent / borane dimethyl sulfide complex / tetrahydrofuran / 20 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

6.1: toluene / 0.02 h

6.2: L,R,R-Jacobsen peptide / toluene / 49 h / -78 - 20 °C

7.1: hydrogen chloride (gas) / 8 h / 20 °C

8.1: N,N'-dimethylbarbituric acid / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / CH₂Cl₂ / 3 h / 35 °C

With hydrogenchloride; 1,3-dimethylbarbituric acid; dimethylsulfide borane complex; boron trifluoride diethyl etherate; Dess-Martin periodane; toluene-4-sulfonic acid; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene; 5.1: Dess-Martin oxidation / 6.2: Jacobsen-Strecker asymmetric reaction / 7.1: Pinner reaction;
DOI:10.1021/ol049619m

Reference yield:

: 216962-29-7
5-(2-phenyl-ethyl)-4-(1-keto-ethyl)-3-isoxazolecarboxylic acid ethyl ester

: 691406-81-2
(S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: BF₃*OEt₂ / 0.17 h / cooling

1.2: 68 percent / lead(IV) acetate / benzene

2.1: 54 percent / borane dimethyl sulfide complex / tetrahydrofuran / 20 °C

3.1: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

4.1: toluene / 0.02 h

4.2: L,R,R-Jacobsen peptide / toluene / 49 h / -78 - 20 °C

5.1: hydrogen chloride (gas) / 8 h / 20 °C

6.1: N,N'-dimethylbarbituric acid / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / CH₂Cl₂ / 3 h / 35 °C

With hydrogenchloride; 1,3-dimethylbarbituric acid; dimethylsulfide borane complex; boron trifluoride diethyl etherate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 3.1: Dess-Martin oxidation / 4.2: Jacobsen-Strecker asymmetric reaction / 5.1: Pinner reaction;
DOI:10.1021/ol049619m