216962-29-7

Upstream product

• 216962-12-8 3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester 
• 15911-11-2 ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate 
• 100-39-0 benzyl bromide 
• 216962-18-4 5-(2-phenyl-ethyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-3-isoxazolecarboxylic acid ethyl ester 

Downstream Products

• 691406-51-6 5-(2-phenyl-ethyl)-4-(2-oxo-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691406-44-7 5-(2-phenyl-ethyl)-4-(2-hydroxy-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691406-81-2 (S)-5-(2-phenyl-ethyl)-4-(2-amino-2-methoxycarbonyl-ethyl)-3-isoxazolecarboxylic acid ethyl ester 
• 691406-73-2 (S)-5-(2-phenyl-ethyl)-4-(N-[allyl]-2-amino-2-methoxycarbonyl-ethyl)-3-izoxazolecarboxylic acid ethyl ester 
• 216962-31-1 5-(2-phenyl-ethyl)-4-(methoxycarbonyl)methyl-3-isoxazolecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of glutamate analogues

Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral

Lateral lithiation of ethyl 4-acetyl-5-methyl-3-isoxazolyl carboxylate with 5,5-dimethyl-1,3-dioxanyl as a directing group

Lateral lithiation of ethyl 4-acetyl-5-methyl-3-isoxazolyl carboxylate, a functionalized isoxazole AMPA analog, occurs cleanly at the C-5 methyl group with 5,5-dimethyl-1,3-dioxanyl as a directing group. The 4-acetyl isoxazole derivatives were transformed selectively by a modified Willgerodt- Kindler reaction into the corresponding homologated methyl esters after deprotection.