C₄₈H₄₄N₆O₉

Base Information

Chemical Name:C₄₈H₄₄N₆O₉
CAS No.:1428248-64-9
Molecular Formula:C₄₈H₄₄N₆O₉
Molecular Weight:848.912
Hs Code.:

C<sub>48</sub>H<sub>44</sub>N<sub>6</sub>O<sub>9</sub>

Synonyms:C₄₈H₄₄N₆O₉

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Chemical Property of C₄₈H₄₄N₆O₉

Chemical Property:

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Technology Process of C₄₈H₄₄N₆O₉

There total 15 articles about C₄₈H₄₄N₆O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: H-Phe-2-ClTrt resin

: 1428248-60-5
(S)-2-(9-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)-3-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 1428248-64-9
C₄₈H₄₄N₆O₉

Guidance literature:: H-Phe-2-ClTrt resin; (S)-2-(9-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)-3-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 22h; 2-chlorotrityl resin

With piperidine; In N,N-dimethyl-formamide; for 0.333333h; 2-chlorotrityl resin

Fmoc-(tBu)Asp-OH; Further stages;
DOI:10.1016/j.bmc.2013.01.020

Reference yield:

: C₉H₉ClN₂O₃

: 1428248-64-9
C₄₈H₄₄N₆O₉

Guidance literature:: Multi-step reaction with 12 steps

1.1: acetic acid; sodium cyanoborohydride / methanol / 2.5 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / 20 °C / Cooling

3.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.5 h / 20 °C

5.1: triethylamine / dimethyl sulfoxide / 26 h / 100 °C

6.1: dmap / acetonitrile / 2 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h

8.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -78 °C

8.2: 1 h / -78 - -30 °C

9.1: cyclohexene; sodium chlorite; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol; water / 2.5 h / Cooling with ice

10.1: palladium on carbon; hydrogen / methanol / 4 h

11.1: sodium carbonate / water; 1,4-dioxane / 0 - 20 °C

11.2: pH 3

12.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h

12.2: 0.33 h

With dmap; sodium chlorite; sodium dihydrogen phosphate monohydrate; oxalyl dichloride; palladium on carbon; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium cyanoborohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; cyclohexene; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 8.1: |Swern Oxidation / 8.2: |Swern Oxidation;
DOI:10.1016/j.bmc.2013.01.020

Reference yield:

: 89639-98-5
(2-chloro-3-nitrophenyl)methanol

: 1428248-64-9
C₄₈H₄₄N₆O₉

Guidance literature:: Multi-step reaction with 14 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane

2.1: acetic acid / methanol / 0.17 h

3.1: acetic acid; sodium cyanoborohydride / methanol / 2.5 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / 20 °C / Cooling

5.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.5 h / 20 °C

7.1: triethylamine / dimethyl sulfoxide / 26 h / 100 °C

8.1: dmap / acetonitrile / 2 h / 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h

10.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -78 °C

10.2: 1 h / -78 - -30 °C

11.1: cyclohexene; sodium chlorite; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol; water / 2.5 h / Cooling with ice

12.1: palladium on carbon; hydrogen / methanol / 4 h

13.1: sodium carbonate / water; 1,4-dioxane / 0 - 20 °C

13.2: pH 3

14.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h

14.2: 0.33 h

With dmap; sodium chlorite; sodium dihydrogen phosphate monohydrate; oxalyl dichloride; palladium on carbon; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium cyanoborohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; cyclohexene; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 10.1: |Swern Oxidation / 10.2: |Swern Oxidation;
DOI:10.1016/j.bmc.2013.01.020