5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

Base Information

Chemical Name:5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)
CAS No.:145643-11-4
Molecular Formula:C₃₃H₄₃N₃O₆
Molecular Weight:577.721
Hs Code.:

Synonyms:5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

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Technology Process of 5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

There total 4 articles about 5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 145643-10-3
5-(p-Cyanophenyl)-pentanoic acid

: (S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

: 145643-11-4
5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 23 ℃; for 20h;
DOI:10.1021/jm00065a003

Reference yield:

: 591-80-0
pent-4-enoic acid

: 145643-11-4
5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / Bu₄NCl, PPh₃, Pd(OAc)2, KOAc / dimethylformamide / 21 h / 23 °C

2: H₂ / 5percent Pd/CaCO₃ / methanol / 1.2 h / 258.6 Torr

3: 80 percent / N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 20 h / 23 °C

With palladium diacetate; tetrabutyl-ammonium chloride; hydrogen; potassium acetate; dicyclohexyl-carbodiimide; triphenylphosphine; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00065a003

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 145643-11-4
5-(p-cyanophenyl)pentanoyl-(S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl)

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / Bu₄NCl, PPh₃, Pd(OAc)2, KOAc / dimethylformamide / 21 h / 23 °C

2: H₂ / 5percent Pd/CaCO₃ / methanol / 1.2 h / 258.6 Torr

3: 80 percent / N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 20 h / 23 °C

With palladium diacetate; tetrabutyl-ammonium chloride; hydrogen; potassium acetate; dicyclohexyl-carbodiimide; triphenylphosphine; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00065a003