3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

Base Information

• Chemical Name: 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE
• CAS No.: 102830-75-1
• Molecular Formula: C6H5BrClNO
• Molecular Weight: 222.469
• Hs Code.: 2933399090
• European Community (EC) Number: 639-404-2
• DSSTox Substance ID: DTXSID70544002
• Wikidata: Q72452948
• Mol file: 102830-75-1.mol

Synonyms:3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE;2-Methoxy-3-Bromo-5-Chloropyridine

Chemical Property of 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.212mmHg at 25°C
• Melting Point: 49.0 to 53.0 °C
• Refractive Index: 1.56
• Boiling Point: 215.803 °C at 760 mmHg
• PKA: -1.24±0.20(Predicted)
• Flash Point: 84.315 °C
• PSA: 22.12000
• Density: 1.65 g/cm³
• LogP: 2.50610
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Chloroform
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 220.92430
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-chloro-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=N1)Cl)Br

Technology Process of 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

There total 2 articles about 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-chloro-2-methoxypyridine (13473-01-3) → 3-Bromo-5-chloro-2-methoxypyridine (102830-75-1)

Guidance literature:

With bromine; sodium acetate; In acetic acid; 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h;;

Reference yield:

2,5 dichloropyridine (16110-09-1) → 3-Bromo-5-chloro-2-methoxypyridine (102830-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / methanol / 68 h / Heating

2: 74 percent / anhydrous sodium acetate, Br₂ / acetic acid / 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h;

With bromine; sodium acetate; In methanol; acetic acid;

Reference yield: 100.0%

N-[4-[(E)-2-[3-tert-butyl-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]vinyl]phenyl]methanesulfonamide + 3-Bromo-5-chloro-2-methoxypyridine (102830-75-1) → N-[4-[(E)-2-[3-tert-butyl-5-(5-chloro-2-methoxy-3-pyridyl)-2-methoxyphenyl]vinyl]phenyl]methanesulfonamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 120 ℃; for 0.583333h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm401266k

upstream raw materials:

5-chloro-2-methoxypyridine

2,5 dichloropyridine

Downstream raw materials:

(E)-5-Chloro-α-<2-(4-chlorophenyl)ethenyl>-2-methoxy-3-pyridinemethanol

(E)-5-chloro-α-<2-(3,4-dichlorophenyl)ethenyl>-2-methoxy-3-pyridinemethanol

3-(5-Chloro-2-methoxy-3-pyridinyl)-1-(3,4-dichlorophenyl)-propan-1-one

3-Bromo-2-methoxy-5-pyridinecarboxaldehyde