1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester

Base Information

• Chemical Name: 1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester
• CAS No.: 6553-86-2
• Molecular Formula: C₁₁H₂₀O₂
• Molecular Weight: 184.279
• Mol file: 6553-86-2.mol

Synonyms:1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester

Chemical Property of 1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• General Description: Based on the provided literature, **1-Methyl-cyclohexancarbons?ure-(1)-isopropylester** is a tertiary carboxylic acid ester derived from the carbonylation of methylcyclohexane using CO in the presence of the superelectrophilic system **CBr₄·2AlBr₃** at low temperature (?40 °C). The reaction proceeds with high selectivity, yielding the corresponding isopropyl ester of the tertiary carboxylic acid formed at the tertiary carbon of the methylcyclohexane framework. This method enables the direct functionalization of cycloalkanes to produce individual, structurally defined esters. (Returned paragraph excludes direct literature descriptions.)

Technology Process of 1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester

There total 5 articles about 1-Methyl-cyclohexancarbonsaeure-⁽¹⁾-isopropylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

cycloheptane (291-64-5) + carbon monoxide (201230-82-2) + isopropyl alcohol (67-63-0,8013-70-5) → cycloheptyl bromide (2404-35-5) + 1-Methyl-cyclohexancarbonsaeure-(1)-isopropylester (6553-86-2)

Guidance literature:

cycloheptane; carbon monoxide; With aluminum tri-bromide; carbon tetrabromide; In various solvent(s); at -40 ℃; for 2h; under 760 Torr;

isopropyl alcohol; In various solvent(s); at -40 - 20 ℃;

DOI:10.1016/S0040-4039(00)01761-5

Reference yield: 82.0%

cycloheptane (291-64-5) + carbon monoxide (201230-82-2) + isopropyl alcohol (67-63-0,8013-70-5) → 1-Methyl-cyclohexancarbonsaeure-(1)-isopropylester (6553-86-2)

Guidance literature:

cycloheptane; carbon monoxide; With 2AlBr₃*CBr₄; In various solvent(s); at -40 ℃; for 2h; under 760 Torr;

isopropyl alcohol; In various solvent(s); at -40 - 0 ℃; for 0.5h;

DOI:10.1023/A:1015091731172

Reference yield: 73.0%

carbon monoxide (201230-82-2) + methyl cyclohexane (82166-21-0) + isopropyl alcohol (67-63-0,8013-70-5) → cycloheptyl bromide (2404-35-5) + 1-Methyl-cyclohexancarbonsaeure-(1)-isopropylester (6553-86-2)

Guidance literature:

carbon monoxide; methyl cyclohexane; With aluminum tri-bromide; carbon tetrabromide; In various solvent(s); at -40 ℃; for 1h; under 760 Torr;

isopropyl alcohol; In various solvent(s); at -40 - 20 ℃;

DOI:10.1016/S0040-4039(00)01761-5

upstream raw materials:

carbon monoxide

methyl cyclohexane

isopropyl alcohol

cycloheptane