1-Piperazineethanethioamide,4-methyl-

Base Information

• Chemical Name: 1-Piperazineethanethioamide,4-methyl-
• CAS No.: 164926-91-4
• Molecular Formula: C7H15N3S
• Molecular Weight: 173.28
• Hs Code.: 2933599090
• Mol file: 164926-91-4.mol

Synonyms:2-(4-Methylpiperazin-1-yl)ethanethioamide;2-(4-Methylpiperazin-1-yl)thioacetamide;

Chemical Property of 1-Piperazineethanethioamide,4-methyl-

Chemical Property:

• Vapor Pressure: 0.00464mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 277 °C at 760 mmHg
• PKA: 12.97±0.29(Predicted)
• Flash Point: 121.3 °C
• PSA: 64.59000
• Density: 1.119 g/cm³
• LogP: 0.09600
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Methyl-piperazin-1-yl)thioacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperazineethanethioamide,4-methyl-

There total 3 articles about 1-Piperazineethanethioamide,4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(4-methyl-1-piperazinyl)acetamide (83808-21-3) → 2-(4-methylpiperazin-1-yl)ethanethioamide (164926-91-4)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; at 60 ℃; for 0.5h;

Reference yield: 37.0%

2-(4-methylpiperazin-1-yl)acetonitrile (874-77-1) → 2-(4-methylpiperazin-1-yl)ethanethioamide (164926-91-4)

Guidance literature:

With pyridine; hydrogen sulfide; triethylamine;

DOI:10.1021/jm058198r

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(4-methylpiperazin-1-yl)ethanethioamide (164926-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / K₂CO₃ / acetonitrile / 75 h

2: 37 percent / H₂S; Et₃N; pyridine

With pyridine; hydrogen sulfide; potassium carbonate; triethylamine; In acetonitrile;

DOI:10.1021/jm058198r

upstream raw materials:

2-(4-methyl-1-piperazinyl)acetamide

2-(4-methylpiperazin-1-yl)acetonitrile

1-methyl-piperazine