1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane
CAS No.:485815-55-2
Molecular Formula:C₅₇H₆₂N₁₀O₆
Molecular Weight:983.183
Hs Code.:

Synonyms:1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

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Chemical Property of 1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

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Technology Process of 1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

There total 4 articles about 1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 112193-83-6
1-benzyl-1,4,7,10-tetraazacyclododecane

: 372520-83-7
ethyl 5'-bromomethyl-6-(2,2'-bipyridine)-carboxylate

: 485815-55-2
1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1055/s-2002-33347

Reference yield:

: 21190-88-5
6-bromopyridine-2-carboxylic acid ethyl ester

: 485815-55-2
1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

2: 72 percent / Br₂ / benzene; H₂O / 0.5 h / Heating; irradiation

3: 51 percent / i-Pr₂EtN / dimethylformamide / 48 h / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene; benzene; 1: Stille reaction;
DOI:10.1055/s-2002-33347

Reference yield:

: 189195-41-3
5-methyl-2-(tri-n-butylstannyl)pyridine

: 485815-55-2
1-benzyl-4,7,10-tri[(6'-ethoxycarbonyl-2,2'-bipyridine-5-yl)methyl]-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

2: 72 percent / Br₂ / benzene; H₂O / 0.5 h / Heating; irradiation

3: 51 percent / i-Pr₂EtN / dimethylformamide / 48 h / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene; benzene; 1: Stille reaction;
DOI:10.1055/s-2002-33347