tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate
CAS No.:1427729-07-4
Molecular Formula:C₂₂H₃₁NO₃
Molecular Weight:357.493
Hs Code.:

Synonyms:tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1427728-80-0
(((4-bromo-2-methylbut-3-yn-2-yl)oxy)methyl)benzene

: 202925-92-6
N-Pent-4-enylcarbamic acid tert-butyl ester

: 1427729-07-4
tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In toluene; at 80 ℃; for 3h; Sealed tube; Inert atmosphere;
DOI:10.1021/jo400254q

Reference yield:

: 50420-73-0
3-(benzyloxy)-3-methylbut-1-yne

: 1427729-07-4
tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate / toluene / 3 h / 80 °C / Sealed tube; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; silver nitrate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In acetone; toluene;
DOI:10.1021/jo400254q

Reference yield:

: 100-39-0
benzyl bromide

: 1427729-07-4
tert-butyl 2-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate / toluene / 3 h / 80 °C / Sealed tube; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; sodium hydride; silver nitrate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In tetrahydrofuran; acetone; toluene; mineral oil;
DOI:10.1021/jo400254q