benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

Base Information

Chemical Name:benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate
CAS No.:871918-46-6
Molecular Formula:C₃₂H₃₀N₂O₄
Molecular Weight:506.601
Hs Code.:

Synonyms:benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

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Chemical Property of benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

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Technology Process of benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

There total 4 articles about benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871918-52-4
[(R)-1-((S)-2-Hydroxy-1-hydroxymethyl-2,2-diphenyl-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

: 871918-46-6
benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP; triethylamine / 1,2-dichloro-ethane / 20 °C

2: 1.453 g / 1,2-dichloro-ethane / Heating

With dmap; triethylamine; In 1,2-dichloro-ethane;
DOI:10.1021/ol052300x

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 871918-46-6
benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; 1,2-dibromoethane / diethyl ether / 5.5 h

1.2: 54 percent / diethyl ether

2.1: isobutyl chloroformate; N-methylmorpholine / CH₂Cl₂ / 0.67 h / -15 °C

2.2: 90 percent / N-methylmorpholine / CH₂Cl₂ / 1 h / 20 °C

3.1: DMAP; triethylamine / 1,2-dichloro-ethane / 20 °C

4.1: 1.453 g / 1,2-dichloro-ethane / Heating

With 4-methyl-morpholine; dmap; magnesium; ethylene dibromide; triethylamine; isobutyl chloroformate; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; 1.2: Grignard reaction;
DOI:10.1021/ol052300x

Reference yield:

: 189937-41-5
(S)-2-amino-1,1-diphenylpropane-1,3-diol

: 871918-46-6
benzyl (R)-1-((S)-4-(hydroxydiphenylmethyl)-4,5-dihydrooxazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-methylmorpholine / CH₂Cl₂ / 0.67 h / -15 °C

1.2: 90 percent / N-methylmorpholine / CH₂Cl₂ / 1 h / 20 °C

2.1: DMAP; triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 1.453 g / 1,2-dichloro-ethane / Heating

With 4-methyl-morpholine; dmap; triethylamine; isobutyl chloroformate; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol052300x