Technology Process of (+)-(1S,5S)-5-isopropenyl-3-[2-(2-methoxy-3-methylphenyl)ethyl]-2,4,4-trimethylcyclohex-2-enyl methyl ether
There total 8 articles about (+)-(1S,5S)-5-isopropenyl-3-[2-(2-methoxy-3-methylphenyl)ethyl]-2,4,4-trimethylcyclohex-2-enyl methyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 90 percent / benzyltriethylammonium bromide; aq. KOH / CH2Cl2 / 24 h / 20 °C
2.1: O3; O2 / methanol / 0.2 h / -90 °C
2.2: 97 percent / NaBH4 / methanol / -50 - 20 °C
3.1: 93 percent / CBr4; PPh3 / CH2Cl2 / 20 h / 20 °C
4.1: Li / tetrahydrofuran / 0.67 h / 15 - 20 °C / ultrasonic irradiation
5.1: 27 mg / PCC / CH2Cl2 / 6 h
6.1: 84 percent / LiAlH4 / diethyl ether / 2 h / -90 °C
7.1: NaH / tetrahydrofuran; dimethylformamide / 1 h / 20 °C
7.2: 72 percent Turnov. / tetrahydrofuran; dimethylformamide / 8 h
With
potassium hydroxide; lithium aluminium tetrahydride; carbon tetrabromide; oxygen; benzyltriethylammonium bromide; lithium; sodium hydride; ozone; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
4.1: Barbier reaction;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: Heating
2.1: 90 percent / benzyltriethylammonium bromide; aq. KOH / CH2Cl2 / 24 h / 20 °C
3.1: O3; O2 / methanol / 0.2 h / -90 °C
3.2: 97 percent / NaBH4 / methanol / -50 - 20 °C
4.1: 93 percent / CBr4; PPh3 / CH2Cl2 / 20 h / 20 °C
5.1: Li / tetrahydrofuran / 0.67 h / 15 - 20 °C / ultrasonic irradiation
6.1: 27 mg / PCC / CH2Cl2 / 6 h
7.1: 84 percent / LiAlH4 / diethyl ether / 2 h / -90 °C
8.1: NaH / tetrahydrofuran; dimethylformamide / 1 h / 20 °C
8.2: 72 percent Turnov. / tetrahydrofuran; dimethylformamide / 8 h
With
potassium hydroxide; lithium aluminium tetrahydride; carbon tetrabromide; oxygen; benzyltriethylammonium bromide; lithium; sodium hydride; ozone; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
1.1: Claisen rearrangement / 5.1: Barbier reaction;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: O3; O2 / methanol / 0.2 h / -90 °C
1.2: 97 percent / NaBH4 / methanol / -50 - 20 °C
2.1: 93 percent / CBr4; PPh3 / CH2Cl2 / 20 h / 20 °C
3.1: Li / tetrahydrofuran / 0.67 h / 15 - 20 °C / ultrasonic irradiation
4.1: 27 mg / PCC / CH2Cl2 / 6 h
5.1: 84 percent / LiAlH4 / diethyl ether / 2 h / -90 °C
6.1: NaH / tetrahydrofuran; dimethylformamide / 1 h / 20 °C
6.2: 72 percent Turnov. / tetrahydrofuran; dimethylformamide / 8 h
With
lithium aluminium tetrahydride; carbon tetrabromide; oxygen; lithium; sodium hydride; ozone; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
3.1: Barbier reaction;
