53948-45-1

Upstream product

• 3354-58-3 2-allyl-6-methylphenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 936-72-1 allyl o-tolyl ether 
• 95-48-7 ortho-cresol 

Downstream Products

• 103857-76-7 2-(2-bromo-propyl)-6-methyl-anisole 
• 386748-49-8 2-(2-methoxy-3-methylphenyl)ethanol 
• 386748-48-7 2-(2-bromoethyl)-6-methylanisole 
• 386748-53-4 (+)-(1R,13S)-3,13-dimethoxy-2-methyl-2,3-seco-19-nor-tax-3,5,7,11-tetraene-2-one 
• 386748-50-1 (+)-(5S)-5-isopropenyl-3-[2-(2-methoxy-3-methylphenyl)ethyl]-2,4,4-trimethylcyclohex-2-enone 
• 386748-51-2 (+)-(1S,5S)-5-isopropenyl-3-[2-(2-methoxy-3-methylphenyl)ethyl]-2,4,4-trimethylcyclohex-2-enol 
• 386748-52-3 (+)-(1S,5S)-5-isopropenyl-3-[2-(2-methoxy-3-methylphenyl)ethyl]-2,4,4-trimethylcyclohex-2-enyl methyl ether 
• 109247-36-1 benzyl-[2-(2-methoxy-3-methyl-phenyl)-1-methyl-ethyl]-amine 
• 1093296-24-2 5-methoxy-6-methyl-3,4-dihydronaphthalen-1-(2H)-one 
• 53948-44-0 c11h16o3 

Relevant academic research and scientific papers

Synthesis and biological activity of novel phenol-conjugates of isoxazolidines

1,3-Dipolar cycloadditions of the phosphonylnitrone with selected allylbenzenes produced mixtures of diastereoisomeric (3-diethoxyphosphoryl)isoxazolidines with good trans/cis diastereoselectivities (d.e. 80%) and good to excellent overall yields. No inhibitory activity against a broad panel of DNA and RNA viruses was detected for (3-diethoxyphosphoryl)isoxazolidines at 250 μM. Isoxazolidines trans-3k : cis-3k (95: 5) slightly reduced human embryonic lung (HEL) cell viability (CC50 = 45 μM). Four out of ten isoxazolidines inhibited the growth of Staphylococcus epidermidis ATCC 12228 (up to 40% for the most active compound). They were also inhibitory against Staphylococcus aureus ATCC 6538 although inhibition did not exceeded 25%. None of the isoxazolidines affected Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 15442 growth.

Enantiospecific synthesis of B-seco-C-aromatic taxanes

A simple and efficient methodology for the enantiospecific synthesis of B-seco-C-aromatic taxanes starting from monoterpene (R)-carvone is described. Coupling of 6,6-dimethylcarvone 5 with appropriate arylethyl bromides followed by oxidation generates the enones 7, 15, 25, which are transformed into the 20-nor-B-seco-C-aromatic taxane derivatives 11, 17 and B-seco-C-aromatic taxane derivative 29 via degradation of the isopropenyl group.