(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

Base Information

Chemical Name:(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid
CAS No.:1373038-19-7
Molecular Formula:C₉H₁₃F₃O₂
Molecular Weight:210.196
Hs Code.:

Synonyms:(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

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Chemical Property of (S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

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Technology Process of (S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

There total 4 articles about (S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1373037-98-9
C₂₁H₂₆F₃NO₃

: 1373038-19-7
(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

: 168297-85-6,352438-06-3
(S)-4-benzyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja302552e

Reference yield:

: 23860-35-7
cyclohexylacetic acid chloride

: 1373038-19-7
(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere

2.2: 17 h / -78 - 45 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C / Inert atmosphere

With tris(triphenylphosphine)ruthenium(II) chloride; n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ja302552e

Reference yield:

: 1373037-72-9
(S)-4-benzyl-3-(2-cyclohexylacetyl)-5,5-dimethyloxazolidin-2-one

: 1373038-19-7
(S)-2-cyclohexyl-3,3,3-trifluoropropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere

1.2: 17 h / -78 - 45 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C / Inert atmosphere

With tris(triphenylphosphine)ruthenium(II) chloride; lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja302552e