23860-35-7

Basic information

• Product Name: CYCLOHEXYLACETYL CHLORIDE 98
• Synonyms: CYCLOHEXYLACETYL CHLORIDE 98;Cyclohexylacetyl chloride 98%
• CAS NO: 23860-35-7
• Molecular Formula: C₈H₁₃ClO
• Molecular Weight: 160.643
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 23860-35-7.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 187 °F(lit.)
• Flash Point: 178 °F
• Appearance: /
• Density: 1.047 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.207mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: CYCLOHEXYLACETYL CHLORIDE 98(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYLACETYL CHLORIDE 98(23860-35-7)
• EPA Substance Registry System: CYCLOHEXYLACETYL CHLORIDE 98(23860-35-7)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 2
• Hazardous Substances Data: 23860-35-7(Hazardous Substances Data)

Usage

General Description

Cyclohexylacetyl chloride 98, also known as CHAC, is a chemical compound with the molecular formula C8H13ClO. It is a colorless to pale yellow liquid with a sweetish, acrid odor. CHAC is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and perfumes. It is also used in the synthesis of various organic compounds, including those used in the production of plastics, polymers, and resins. CHAC is a highly reactive compound and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system if not properly managed.

InChI:InChI=1/C8H13ClO/c9-8(10)6-7-4-2-1-3-5-7/h7H,1-6H2

Upstream product

• 4709-59-5 ethyl 2-(1-cyclohexenyl)acetate 
• 79-37-8 oxalyl dichloride 
• 5452-75-5 ethyl 2-cyclohexylacetate 
• 7719-09-7 thionyl chloride 
• 5292-21-7 Cyclohexylacetic acid 
• 103-82-2 phenylacetic acid 

Downstream Products

• 58987-23-8 2-cyclohexyl-1-(4-methoxyphenyl)ethan-1-one 
• 118982-61-9 17-(2-cyclohexyl-ethyl)-morphinan-3-ol 
• 708276-22-6 2-cyclohexyl-1-(4-methylsulfanylphenyl)ethanone 
• 134560-43-3 2-cyclohexyl-N-methoxy-N-methylacetamide 
• 779318-92-2 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-methanesulfonamide 
• 752977-73-4 (2-cyclohexyl-2-piperazin-1-yl-ethyl)-diethyl-amine 
• 444893-43-0 4-(1-cyclohexyl-2-oxo-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 727974-08-5 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-N-ethyl-acetamide 
• 444893-46-3 4-(2-amino-1-cyclohexyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444893-42-9 4-(1-cyclohexyl-2-hydroxy-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 786635-59-4 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-N-ethyl-methanesulfonamide 
• 444893-17-8 4-(carboxy-cyclohexyl-methyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444893-16-7 4-(cyclohexyl-methoxycarbonyl-methyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 788151-14-4 1-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-pyrrolidine-2,5-dione 

Relevant articles and documents

Hydroxamic Acid-Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions

Lysine acylation of proteins is an essential chemical reaction for posttranslational modification and as a means of protein modification in various applications. N,N-Dimethyl-4-aminopyridine (DMAP) derivatives are widely-used catalysts for lysine acylatio

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

Remote Directed Isocyanation of Unactivated C(sp3)-H Bonds: Forging Seven-Membered Cyclic Ureas Enabled by Copper Catalysis

Reported herein is an unprecedented copper-catalyzed site-selective ?-C(sp3)-H bonds activation of aliphatic sulfonamides for constructing the synthetically useful seven-membered N-heterocycles. A key to success is the use of in-situ-formed amide radicals, to activate the inert C(sp3)-H bond, and inexpensive TMSNCO, as a coupling reagent under mild conditions. To the best of our knowledge, this represents the first use of alkylamine derivatives as a five-membered synthon to prepare a seven-membered N-heterocycles.