(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

Base Information

Chemical Name:(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol
CAS No.:932725-35-4
Molecular Formula:C₂₃H₂₃NO₄S
Molecular Weight:409.506
Hs Code.:

Synonyms:(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

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Chemical Property of (S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

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Technology Process of (S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

There total 10 articles about (S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 932725-28-5
(S)-N-(2-hydroxy-benzyl)-N-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-4-methyl-benzenesulfonamide

: 932725-35-4
(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.10.126 DOI:10.1016/j.bmcl.2009.10.115

Reference yield:

: C₂₃H₂₅NO₅S

: 932725-35-4
(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.10.013

Reference yield:

: 3381-87-1
2-benzyloxybenzyl alcohol

: 932725-35-4
(S)-4-[4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-3-ylmethyl]-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2585.81 Torr / Inert atmosphere

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement / 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.10.013