5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

Base Information

Chemical Name:5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
CAS No.:741709-63-7
Molecular Formula:C12H15BN2O2
Molecular Weight:230.074
Hs Code.:2934999090
European Community (EC) Number:804-926-3
DSSTox Substance ID:DTXSID00585943
Wikidata:Q72459066
Mol file:741709-63-7.mol

Synonyms:741709-63-7;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile;2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER;5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE-2-CARBONITRILE;MFCD06657825;2-CYANO PYRIDINE -5-BORONIC ACID PINACOL ESTER;2-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;(2-CYANOPYRIDIN-5-YL)BORONIC ACID PINACOL ESTER;2-cyanopyridine-5-boronic acid pinacole ester;2-Pyridinecarbonitrile, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;SCHEMBL182915;(6-CYANOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;DTXSID00585943;IXTBQKLZPOYJFJ-UHFFFAOYSA-N;5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile;RB2013;AKOS015919980;AB25702;CS-W003994;GS-5844;AC-25836;BP-10633;SY010514;6-Cyano-3-pyridylboronic Acid Pinacol Ester;AM20061478;C3126;A19562;EN300-318549;J-509232;2-cyanopyridine-5-boronic acid pinacol ester, AldrichCPR;Z1258919780;2-(6-Cyano-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-cyano-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyridine;5-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)picolinonitrile;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine-2-carbonitrile;5-(4,4,5,5-tetramethyl-[1,3,2]dioxa borolan-2-yl)-pyridine-2-carbonitrile;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl) -pyridine-2-carbonitrile;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carbonitrile

Suppliers and Price of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
2-Cyanopyridine-5-boronic acid pinacol ester
500mg
$ 333.00

TRC
2-Cyanopyridine-5-boronicacidpinacolester
250mg
$ 55.00

TRC
2-Cyanopyridine-5-boronicacidpinacolester
100mg
$ 45.00

TCI Chemical
2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(T)
200mg
$ 44.00

TCI Chemical
2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(T)
1g
$ 151.00

Synthonix
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile 97%
25g
$ 600.00

Synthonix
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile 97%
5g
$ 130.00

Matrix Scientific
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile 95+%
1g
$ 65.00

Labseeker
2-cyanopyridine-5-boronicacid 97
25g
$ 1100.00

Crysdot
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile 97%
25g
$ 452.00

Total 65 raw suppliers

Chemical Property of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

Chemical Property:

Vapor Pressure:1.09E-05mmHg at 25°C
Melting Point:105-106℃
Refractive Index:1.506
Boiling Point:370.7 °C at 760 mmHg
PKA:-0.33±0.12(Predicted)
Flash Point:178 °C
PSA：55.14000
Density:1.1 g/cm³
LogP:1.25248
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Water Solubility.:Slightly soluble in water.
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:230.1226579
Heavy Atom Count:17
Complexity:332

Purity/Quality:

99%, ^*data from raw suppliers

2-Cyanopyridine-5-boronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 37/38-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B1(OC(C(O1)(C)C)(C)C)C2=CN=C(C=C2)C#N
Uses suzuki reaction It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is used in suzuki reactions.

Technology Process of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

There total 3 articles about 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 97483-77-7
2-Cyano-5-bromopyridine

: 73183-34-3
bis(pinacol)diborane

: 741709-63-7
2-cyanopyridine-5-boronic acid pinacol ester

Guidance literature:: With potassium acetate; palladium dichloride; In dichloromethane; dimethyl sulfoxide; at 90 ℃; for 6h;
DOI:10.1021/jm400508e

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 741709-63-7
2-cyanopyridine-5-boronic acid pinacol ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / I₂; aq. NH₃ / tetrahydrofuran / 4 h / 20 °C

2: 64 percent / PdCl₂(dppf); KOAc / dimethylsulfoxide / 25 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; iodine; potassium acetate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.11.064

Reference yield:

: 741709-63-7
2-cyanopyridine-5-boronic acid pinacol ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 4h;