(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate
CAS No.:1574542-90-7
Molecular Formula:C₂₉H₃₄N₂O₆
Molecular Weight:506.599
Hs Code.:

Synonyms:(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

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Technology Process of (R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: (R)-tert-butyl 3-(4-(N-allyl-2-(4-cyclopropylphenoxy)but-2-enamido)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

: 1574542-90-7
(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 960401-35-8
(R)-tert-butyl 3-(2-methoxy-4-nitrophenoxy)pyrrolidine-1-carboxylate

: 1574542-90-7
(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 - 20 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile;

Reference yield:

: 132945-75-6
(S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate

: 1574542-90-7
(R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Reflux

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

4.2: 0 - 20 °C

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;