(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

Base Information

Chemical Name:(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide
CAS No.:202810-84-2
Molecular Formula:C₂₃H₂₆N₂O
Molecular Weight:346.472
Hs Code.:

Synonyms:(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

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Chemical Property of (2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

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Technology Process of (2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

There total 3 articles about (2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 202810-83-1
N-methyl-N-((1R)-1-(N-methyl-N-phenethylcarbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

: 202810-84-2
(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 147577-61-5
(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

: 202810-84-2
(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: 100 percent / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

2.1: 25 percent / CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 589-08-2
N-Methyl-N-phenethylamine

: 202810-84-2
(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: 100 percent / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

2.1: 25 percent / CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis;
DOI:10.1016/S0223-5234(00)00160-4