N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester
• CAS No.: 202811-07-2
• Molecular Formula: C₃₆H₄₇N₃O₄
• Molecular Weight: 585.787

Synonyms:N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester

Chemical Property of N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester

There total 4 articles about N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-5-(N-(tert-butoxycarbonyl)-N-methylamino)-5-methylhex-2-enoic acid (193086-50-9) + (2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide (202810-84-2) → N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester (202811-07-2)

Guidance literature:

(2E)-5-(N-(tert-butoxycarbonyl)-N-methylamino)-5-methylhex-2-enoic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid (147577-61-5) → N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester (202811-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: 100 percent / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

2.1: 25 percent / CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

3.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0 °C

3.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis / 3.1: Addition / 3.2: Condensation;

DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

N-Methyl-N-phenethylamine (589-08-2) → N-methyl-N-((3E)-4-(N-methyl-N-((1R)-1-(N-methyl-N-phenylcarbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)-1,1-dimethylbut-3-enyl)carbamic acid tert-butyl ester (202811-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: 100 percent / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

2.1: 25 percent / CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

3.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0 °C

3.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis / 3.1: Addition / 3.2: Condensation;

DOI:10.1016/S0223-5234(00)00160-4

upstream raw materials:

(2E)-5-(N-(tert-butoxycarbonyl)-N-methylamino)-5-methylhex-2-enoic acid

(2R)-2-(methylamino)-3-(2-naphthyl)propionic acid N-methyl-N-phenethylamide

(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

N-Methyl-N-phenethylamine

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