2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

Base Information

Chemical Name:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine
CAS No.:1361570-67-3
Molecular Formula:C₁₇H₁₁F₂N₇O₂
Molecular Weight:383.317
Hs Code.:

Synonyms:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

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Chemical Property of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

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Technology Process of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

There total 14 articles about 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1361570-66-2
3-(4-chloro-5-nitropyrimidin-2-yl)-5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine

: 1361570-67-3
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

Guidance literature:: With ammonia; In N,N-dimethyl-formamide; isopropyl alcohol; at 60 ℃; for 1.5h;

Reference yield:

: 1350653-24-5
5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

: 1361570-67-3
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 2 h / 150 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: Reflux

3.1: para-xylene / 5 h / Reflux

4.1: trichlorophosphate / sulfolane / 1 h / 120 °C

5.1: ammonia / N,N-dimethyl-formamide; isopropyl alcohol / 1.5 h / 60 °C

With ammonia; sodium methylate; trichlorophosphate; In sulfolane; methanol; para-xylene; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1361232-73-6
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

: 1361570-67-3
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: Reflux

3.1: para-xylene / 5 h / Reflux

4.1: trichlorophosphate / sulfolane / 1 h / 120 °C

5.1: ammonia / N,N-dimethyl-formamide; isopropyl alcohol / 1.5 h / 60 °C

With pyridine; ammonia; sodium methylate; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; sulfolane; methanol; para-xylene; N,N-dimethyl-formamide; isopropyl alcohol;