6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:79624-77-4
Molecular Formula:C₁₇H₁₉NO₄*ClH
Molecular Weight:337.803
Hs Code.:

Synonyms:6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Chemical Property of 6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 5 articles about 6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79624-69-4
1-(4-benzyloxybenzyl)-6,7-bisbenzyloxy-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 79624-77-4
6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1039/P19810002030

Reference yield:

: 39188-62-0
2-(4-(benzyloxy)phenyl)acetyl chloride

: 79624-77-4
6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1 h

2: phosphorus oxychloride / acetonitrile / 0.33 h / Heating

3: 84 percent / sodium borohydride / methanol / 0.5 h / 20 °C

4: hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / methanol / 760 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1039/P19810002030

Reference yield:

: 6547-53-1
2-[4-(benzyloxy)benzyl]acetic acid

: 79624-77-4
6,7-dihydroxy-1-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / benzene / 0.5 h

2: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1 h

3: phosphorus oxychloride / acetonitrile / 0.33 h / Heating

4: 84 percent / sodium borohydride / methanol / 0.5 h / 20 °C

5: hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / methanol / 760 Torr

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; N,N-dimethyl-formamide; trichlorophosphate; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1039/P19810002030