4-BENZYLOXYPHENYLACETYL CHLORIDE

Base Information

• Chemical Name: 4-BENZYLOXYPHENYLACETYL CHLORIDE
• CAS No.: 39188-62-0
• Molecular Formula: C15H13 Cl O2
• Molecular Weight: 260.72
• Hs Code.: 2918990090
• European Community (EC) Number: 678-027-8
• DSSTox Substance ID: DTXSID70463466
• Nikkaji Number: J1.610.498A
• Wikidata: Q82288353
• Mol file: 39188-62-0.mol

Synonyms:Acetylchloride, [p-(benzyloxy)phenyl]- (5CI); 2-[4-(Phenylmethoxy)phenyl]acetylchloride; 4-Benzyloxyphenylacetyl chloride; 4-Phenylmethoxyphenylacetylchloride

Chemical Property of 4-BENZYLOXYPHENYLACETYL CHLORIDE

Chemical Property:

• Melting Point: 74°C
• Boiling Point: 387.6oC at 760 mmHg
• Flash Point: 142.3oC
• PSA: 26.30000
• Density: 1.21g/cm3
• LogP: 3.57350
• Solubility.: soluble in Methanol,Toluene
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 260.0604073
• Heavy Atom Count: 18
• Complexity: 253

Purity/Quality:

98% ^*data from raw suppliers

4-Benzyloxyphenylacetyl Chloride ^*data from reagent suppliers

Safty Information:

• Statements: 34-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)CC(=O)Cl

Technology Process of 4-BENZYLOXYPHENYLACETYL CHLORIDE

There total 8 articles about 4-BENZYLOXYPHENYLACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ N-{2-(3-methoxyphenyl)ethyl}-N-phenyl-2-{4-(phenylmethoxy)phenyl}acetamide (295318-81-9) + 2-(4-(benzyloxy)phenyl)acetyl chloride (39188-62-0)

Guidance literature:

Reference yield: 84.2%

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → 2-(4-(benzyloxy)phenyl)acetyl chloride (39188-62-0)

Guidance literature:

With thionyl chloride; In chloroform; Reflux;

DOI:10.1021/jm101115u

Reference yield: 70.0%

→ 4'-fluoro-N-(3-methoxyphenethyl)aniline (295318-86-4) + 2-(4-(benzyloxy)phenyl)acetyl chloride (39188-62-0)

Guidance literature:

upstream raw materials:

2-[4-(benzyloxy)benzyl]acetic acid

2-[4-(benzyloxy)phenyl]acetonitrile

4-hydroxyphenylacetate

benzyl chloride

Downstream raw materials:

(4-benzyloxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)

(4-benzyloxy-phenyl)-acetic acid-(4-hydroxy-3-methoxy-phenethylamide)

4-benzyloxybenzene-acetamide

(4-benzyloxy-phenyl)-acetic acid-(2,2-diethoxy-ethylamide)