5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

Base Information

Chemical Name:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one
CAS No.:1429439-59-7
Molecular Formula:C₃₁H₃₄ClN₃O₅
Molecular Weight:564.081
Hs Code.:

Synonyms:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

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Chemical Property of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

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Technology Process of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

There total 10 articles about 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1429439-57-5
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

: 1429439-59-7
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1429439-48-4
1-ethyl-5-nitro-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-3-carboxylic acid

: 1429439-59-7
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 5 h / 2585.81 Torr / Inert atmosphere

2: hydrogenchloride; sodium nitrite / water / 5 h / 45 °C / Inert atmosphere

3: sulfuric acid / 20 h / 95 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

5: water; potassium hydroxide / methanol / 3 h / Inert atmosphere; Reflux

6: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

7: sodium tetrahydroborate / ethanol / 1.25 h / 20 °C / Inert atmosphere; Cooling with ice

8: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere

9: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; sulfuric acid; palladium on activated charcoal; water; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1429439-52-0
4-methoxybenzyl 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carboxylate

: 1429439-59-7
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4-(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: water; potassium hydroxide / methanol / 3 h / Inert atmosphere; Reflux

2: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / ethanol / 1.25 h / 20 °C / Inert atmosphere; Cooling with ice

4: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere

5: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; water; sodium tris(acetoxy)borohydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;