1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE

Base Information

• Chemical Name: 1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
• CAS No.: 847997-88-0
• Molecular Formula: C8H8 Cl2 N2 O2 S
• Molecular Weight: 267.13
• Hs Code.: 2933990090
• Mol file: 847997-88-0.mol

Synonyms:1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE

Chemical Property of 1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE

Chemical Property:

• Melting Point: 173 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• Boiling Point: 445.2±55.0 °C(Predicted)
• PKA: 8.88±0.40(Predicted)
• PSA: 66.58000
• Density: 1.489±0.06 g/cm3(Predicted)
• LogP: 3.15630

Purity/Quality:

NLT 98% ^*data from raw suppliers

1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE

There total 1 articles about 1,1-DIOXIDE-6-CHLORO-3-(CHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloroethanal (107-20-0) + 2-amino-4-chlorobenzenesulfonamide (4140-83-4) → 6-chloro-3-chloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazin 1,1-dioxide (847997-88-0)

Guidance literature:

With ammonium chloride; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1016/j.bmc.2004.10.055

Reference yield: 86.0%

6-chloro-3-chloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazin 1,1-dioxide (847997-88-0) + (4-hydroxyphenyl)methanol (623-05-2) → 4-(6-chloro-3-chloromethyl-1,1-dioxo-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl)-phenol

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2004.10.055

Reference yield: 70.0%

6-chloro-3-chloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazin 1,1-dioxide (847997-88-0) + 3-Nitrobenzyl alcohol (619-25-0) → 6-chloro-3-chloromethyl-2-(3-nitro-benzyl)-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2004.10.055

upstream raw materials:

2-chloroethanal

2-amino-4-chlorobenzenesulfonamide