(3-Chloro-5-methoxyphenyl)methanol

Base Information

• Chemical Name: (3-Chloro-5-methoxyphenyl)methanol
• CAS No.: 82477-68-7
• Molecular Formula: C8H9ClO2
• Molecular Weight: 172.611
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID60512715
• Wikidata: Q82372081
• Mol file: 82477-68-7.mol

Synonyms:(3-CHLORO-5-METHOXYPHENYL)METHANOL;82477-68-7;3-CHLORO-5-METHOXYBENZYL ALCOHOL;3-chloro-5-methoxyphenyl methanol;BENZENEMETHANOL,3-CHLORO-5-METHOXY-;SCHEMBL586319;DTXSID60512715;OELQQMWFPQWRGF-UHFFFAOYSA-N;MFCD08234652;AKOS006284493;MB05597;AS-47390;CS-0139074;F13565;EN300-3472476;Z1198176471

Chemical Property of (3-Chloro-5-methoxyphenyl)methanol

Chemical Property:

• Boiling Point: 282.156 °C at 760 mmHg
• Flash Point: 124.444 °C
• PSA: 29.46000
• Density: 1.24 g/cm³
• LogP: 1.84090
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.0291072
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

99% ^*data from raw suppliers

(3-chloro-5-methoxyphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)CO)Cl

Technology Process of (3-Chloro-5-methoxyphenyl)methanol

There total 5 articles about (3-Chloro-5-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methoxy-5-chlorobenzaldehyde (164650-68-4) → (3-chloro-5-methoxyphenyl)methanol (82477-68-7)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In ethanol;

Reference yield: 54.0%

2-chloro-6-hydroxymethyl-4-methoxyaniline (82477-64-3) → (3-chloro-5-methoxyphenyl)methanol (82477-68-7)

Guidance literature:

With hydrogenchloride; hypophosphorous acid; sodium nitrite; In 1,4-dioxane; water; at 0 ℃; for 20h;

Reference yield:

3-chloro-5-methoxy-benzoic acid (82477-67-6) → (3-chloro-5-methoxyphenyl)methanol (82477-68-7)

Guidance literature:

3-chloro-5-methoxy-benzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

2-chloro-6-hydroxymethyl-4-methoxyaniline

3-methyl-1,4-benzoquinone 4-oxime

3-chloro-5-methoxy-benzoic acid

3-methoxy-5-chlorobenzaldehyde

Downstream raw materials:

methanesulfonic acid 3-chloro-5-methoxybenzyl ester

C₁₀H₁₃ClO₂

C₂₆H₃₃N₅O₂Si

C₁₄H₂₃ClO₂Si