164650-68-4Relevant academic research and scientific papers
Inhibitors of Serine Proteases
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, (2010/12/26)
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
IN VIVO IMAGING COMPOUNDS
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, (2009/07/03)
The invention relates to a compound of formula (I) having use for in vivo imaging of the NR2B subtype of the NMDA receptor. [image]
INHIBITORS OF SERINE PROTEASES FOR THE TREATMENT OF HCV INFECTIONS
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Page/Page column 475-476, (2008/12/07)
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
INHIBITORS OF SERINE PROTEASES
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Page/Page column 306, (2010/11/26)
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.
Mandelic acid derivatives and their use as throbin inhibitors
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Page/Page column 16, (2008/06/13)
There is provided a compound of formula I wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
IMMEDIATE RELEASE PHARMACEUTICAL FORMULATION
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Page 19, (2010/02/04)
According to the present invention there is provided an immediate release pharmaceutical formulation comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituen
MODIFIED RELEASE PHARMACEUTICAL FORMULATION
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Page 21, (2010/02/04)
A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents;R2 represents hydrogen, hydroxy, methoxy
PHARMACEUTICAL COMBINATION
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Page 39; 40, (2010/02/04)
There is provided a combination product comprising: (1) a compound of claim 1 in WO 02/44145 or a compound of claim 20 in WO 02/44145 (or derivative thereof)or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 of WO 01/28992 or (2) a compound of Claim 34 of WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts thereof) for use in treating arrhythmia or a coagulation controlled complication thereof.
AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS
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, (2008/06/13)
There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.
