2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE HYDROCHLORIDE
• CAS No.: 126728-21-0
• Molecular Formula: C₇H₄ClN₃O*ClH
• Molecular Weight: 218.042
• Hs Code.: 2933990090
• Mol file: 126728-21-0.mol

Synonyms:2-chloro-pyrido[3,2-e]pyrimidin-4-ol;2-chloro-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine hydrochloride;2-chloropyrido[2,3-d]pyrimidin-4-ol;2-chloropyrido[2,3-d]pyrimidin-4(1H)-one;

Chemical Property of 2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Boiling Point: 325.8ºC at 760 mmHg
• Flash Point: 150.8ºC
• PSA: 58.64000
• Density: 1.598g/cm3
• LogP: 1.77350

Purity/Quality:

97% ^*data from raw suppliers

2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONEHYDROCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE HYDROCHLORIDE

There total 1 articles about 2-CHLOROPYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,4-dichloropyrido[2,3-d]pyrimidine (126728-20-9) → 2-chloro-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidine hydrochloride (126728-21-0)

Guidance literature:

With sodium hydroxide; Ambient temperature;

DOI:10.1016/0223-5234(89)90001-9

Reference yield: 60.0%

4-nitro-aniline (100-01-6,104810-17-5) + 2-chloro-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidine hydrochloride (126728-21-0) → 2-(4-Nitro-phenylamino)-3H-pyrido[2,3-d]pyrimidin-4-one (126728-05-0)

Guidance literature:

In N,N-dimethyl-formamide; for 7h; Heating;

DOI:10.1016/0223-5234(89)90001-9

Reference yield: 60.0%

2-chloro-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidine hydrochloride (126728-21-0) + N-acetyl-p-phenylenediamine (122-80-5) → N-[4-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]-acetamide (126728-06-1)

Guidance literature:

In N,N-dimethyl-formamide; for 7h; Heating;

DOI:10.1016/0223-5234(89)90001-9

upstream raw materials:

2,4-dichloropyrido[2,3-d]pyrimidine

Downstream raw materials:

2-(4-Benzoyl-phenylamino)-3H-pyrido[2,3-d]pyrimidin-4-one

2-(4-Nitro-phenylamino)-3H-pyrido[2,3-d]pyrimidin-4-one

4-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-benzenesulfonamide

N-[4-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]-acetamide