(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

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Chemical Name:(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide
CAS No.:1410884-81-9
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

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Chemical Property of (E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

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Technology Process of (E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

There total 7 articles about (E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1410884-63-7
N-(2-(tert-butylamino)-2-oxo-1-(1-(p-tolyl)-1H-pyrrol-2-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

: 1410884-81-9
(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

: 1410885-01-6
N-(tert-butyl)-7-(4-methoxybenzyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide

Guidance literature:: With platinum(II) chloride; In chloroform-d1; at 50 ℃; for 14h; regioselective reaction;
DOI:10.1039/c2cc35900f

Reference yield: 35.0%

: 1410884-63-7
N-(2-(tert-butylamino)-2-oxo-1-(1-(p-tolyl)-1H-pyrrol-2-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

: 1410884-81-9
(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

Guidance literature:: With triphenylphosphinegold(I) triflate; In chloroform-d1; at 50 ℃; for 3h; regioselective reaction;
DOI:10.1039/c2cc35900f

Reference yield:

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 1410884-81-9
(E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 48 h / 50 °C

2: triphenylphosphinegold(I) triflate / chloroform-d1 / 3 h / 50 °C

With triphenylphosphinegold(I) triflate; sodium sulfate; In methanol; chloroform-d1;
DOI:10.1039/c2cc35900f