(S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

Base Information

• Chemical Name: (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid
• CAS No.: 152357-03-4
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 152357-03-4.mol

Synonyms:(S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

Chemical Property of (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

There total 4 articles about (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester (113089-15-9) → (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid (152357-03-4)

Guidance literature:

With sodium hydroxide; water; In 1,4-dioxane; at 0 ℃; for 0.5h;

DOI:10.1021/ol015626o

Reference yield:

C12H13NO5 → C12H15NO5 + (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid (152357-03-4)

Guidance literature:

With C₆₀H₆₀P₂Rh⁽¹⁺⁾*ClO₄^(1-); hydrogen; In tetrahydrofuran; at 24 ℃; for 72h; under 760.051 Torr; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja903089f

Reference yield:

(S)-2-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride (67423-44-3) + methyl chloroformate (79-22-1) → (S)-2-((methoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid (152357-03-4)

Guidance literature:

With sodium carbonate; sodium hydroxide; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

(S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester

(S)-2-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride

methyl chloroformate

Downstream raw materials:

(S)-[1-methoxycarbamoyl-2-(4-methoxyphenyl)-ethyl]-carbamic acid methyl ester

(1R,2S,5S)-2-[hydroxy-[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-4-methyl-dispiro[1,4-diazabicyclo[3.2.1]octan-3-one-7,1'-cyclohexane-4',2''-[1,3]dioxolane]

(S)-(1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-yl)-methyl-carbamic acid benzyl ester

(S)-(9-methoxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-yl)-methyl-carbamic acid benzyl ester