2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on

Base Information

• Chemical Name: 2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on
• CAS No.: 149862-20-4
• Molecular Formula: C₂₀H₂₀O₄
• Molecular Weight: 324.376
• Mol file: 149862-20-4.mol

Synonyms:2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on

Chemical Property of 2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on

There total 2 articles about 2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 2-(3',4'-dimethoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one (149862-20-4)

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield: 76.0%

(3,4-dimethoxyphenyl)methanol (93-03-8) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on (149862-20-4)

Guidance literature:

With (4-Me)Triaz(NHPⁱPr₂)₂Mn(CO)₂Br; caesium carbonate; In tert-Amyl alcohol; at 135 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01327

Reference yield: 89.0%

2-(3',4'-dimethoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one (149862-20-4) → 2-(3',4'-dimethoxybenzyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one (149862-21-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1039/c6ra02663j

upstream raw materials:

(3,4-dimethoxyphenyl)methanol

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

Spiro-<3'-(3,4-dimethoxyphenyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalin-2,2'-oxiran>

2-(3',4'-dimethoxybenzyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

2-(3,4-Dimethoxybenzyl)-2-hydroxy-6-methoxy-3,4-dihydro-(2H)-naphthalin-1-on

2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin